解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::We elucidated genomic and transcriptomic changes that accompany the evolution of melanoma from pre-malignant lesions by sequencing DNA and RNA from primary melanomas and their adjacent precursors, as well as matched primary tumors and regional metastases. In total, we analyzed 230 histopathologically distinct areas of...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2018.06.005
更新日期:2018-07-09 00:00:00
abstract::The co-engagement of fragment crystallizable (Fc) gamma receptors (FcγRs) with the Fc region of recombinant immunoglobulin monoclonal antibodies (mAbs) and its contribution to therapeutic activity has been extensively studied. For example, Fc-FcγR interactions have been shown to be important for mAb-directed effector ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2018.05.005
更新日期:2018-06-11 00:00:00
abstract::Besides their function in limiting blood loss and promoting wound healing, experimental evidence has highlighted platelets as active players in all steps of tumorigenesis including tumor growth, tumor cell extravasation, and metastasis. Additionally, thrombocytosis in cancer patients is associated with adverse patient...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/j.ccell.2018.03.002
更新日期:2018-06-11 00:00:00
abstract::Somatic genetic alterations of IKZF1, which encodes the lymphoid transcription factor IKAROS, are common in high-risk B-progenitor acute lymphoblastic leukemia (ALL) and are associated with poor prognosis. Such alterations result in the acquisition of stem cell-like features, overexpression of adhesion molecules causi...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2018.03.021
更新日期:2018-05-14 00:00:00
abstract::Identifying contexts in which cancer cells become addicted to specific nutrients is critical for developing targeted metabolic therapies. In this issue of Cancer Cell, Momcilovic et al. report that suppressed glycolysis following mTOR inhibition is countered by adaptive glutamine catabolism in lung squamous cell carci...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2018.04.009
更新日期:2018-05-14 00:00:00
abstract::Obesity is a leading risk factor for cancer. However, understanding the crosstalk between adipocytes and tumor cells in vivo, independently of dietary contributions, is a major gap in the field. Here we used a prostate cancer (PCa) mouse model in which the signaling adaptor p62/Sqstm1 is selectively inactivated in adi...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2018.03.001
更新日期:2018-04-09 00:00:00
abstract::Metastases arising from tumors have the proclivity to colonize specific organs, suggesting that they must rewire their biology to meet the demands of the organ colonized, thus altering their primary properties. Each metastatic site presents distinct metabolic challenges to a colonizing cancer cell, ranging from fuel a...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/j.ccell.2018.02.001
更新日期:2018-03-12 00:00:00
abstract::Therapies for KRas cancers remain a major clinical need. In the current issue of Cancer Cell, Sanclemente and coworkers in Mariano Barbacid's group validate c-Raf as a prime target for these cancers. c-Raf ablation caused regression of advanced KRasG12V/Trp53 tumors, without obvious systemic toxicity and without affec...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2018.01.017
更新日期:2018-02-12 00:00:00
abstract::Oncogene-induced senescence, e.g., in melanocytic nevi, terminates the expansion of pre-malignant cells via transcriptional silencing of proliferation-related genes due to decoration of their promoters with repressive trimethylated histone H3 lysine 9 (H3K9) marks. We show here that structurally distinct H3K9-active d...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2018.01.002
更新日期:2018-02-12 00:00:00
abstract::The link between GBM molecular subtype and response to treatment remains undefined. In this issue of Cancer Cell, Cosset and colleagues define a subpopulation of patients within the proneural/classical subtype sensitive to integrin blockade because of a Glut3 addiction. These findings reveal context-dependent druggabl...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2017.11.017
更新日期:2017-12-11 00:00:00
abstract::In this issue of Cancer Cell, Kumar et al. describe how CSF1R blockade induces not only an expected deprivation of tumor-associated macrophages, but also an accumulation of tumor-infiltrating polymorphonuclear mononuclear cells caused by Cxcl-1 released from cancer-associated fibroblasts. ...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2017.10.012
更新日期:2017-11-13 00:00:00
abstract::Bladder cancer incurs a higher lifetime treatment cost than other cancers due to frequent recurrence of non-invasive disease. Improved prognostic biomarkers and localized therapy are needed for this large patient group. We defined two major genomic subtypes of primary stage Ta tumors. One of these was characterized by...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2017.08.005
更新日期:2017-11-13 00:00:00
abstract::Neuroblastoma, an embryonal cancer of neural crest origin, shows metastases frequently at diagnosis. In this issue of Cancer Cell, Delloye-Bourgeois and colleagues demonstrate that neuroblastoma cell lines and patient-derived xenografts engraft and adopt a metastatic program in chick embryos. They identify Sema3C as a...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2017.09.012
更新日期:2017-10-09 00:00:00
abstract::Chimeric antigen receptor (CAR) therapy targeting CD19 has yielded remarkable outcomes in patients with acute lymphoblastic leukemia. To identify potential CAR targets in acute myeloid leukemia (AML), we probed the AML surfaceome for overexpressed molecules with tolerable systemic expression. We integrated large trans...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2017.09.004
更新日期:2017-10-09 00:00:00
abstract::LMO1 is a high-risk neuroblastoma susceptibility gene, but how LMO1 cooperates with MYCN in neuroblastoma tumorigenesis is unclear. In this issue of Cancer Cell, Zhu et al. develop a novel zebrafish model that elucidates a mechanism by which LMO1 and MYCN synergistically initiate neuroblastoma and contribute to metast...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2017.08.014
更新日期:2017-09-11 00:00:00
abstract::Whether metastasis-specific genetic alterations exist remains controversial. The study by Yates et al. in this issue of Cancer Cell provides evidence that metastases emerge late during primary breast cancer progression and that additional driver mutations are often acquired, posing both challenges and opportunities fo...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2017.07.011
更新日期:2017-08-14 00:00:00
abstract::Although high c-Myc protein expression is observed alongside MYC amplification in some cancers, in most cases protein overexpression occurs in the absence of gene amplification, e.g., T cell lymphoma (TCL). Here, Ca2+/calmodulin-dependent protein kinase II γ (CAMKIIγ) was shown to stabilize the c-Myc protein by direct...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2017.06.001
更新日期:2017-07-10 00:00:00
abstract::Amplification of 1q21 occurs in approximately 30% of de novo and 70% of relapsed multiple myeloma (MM) and is correlated with disease progression and drug resistance. Here, we provide evidence that the 1q21 amplification-driven overexpression of ILF2 in MM promotes tolerance of genomic instability and drives resistanc...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2017.05.011
更新日期:2017-07-10 00:00:00
abstract::Immunotherapy has changed the landscape of cancer treatment. Checkpoint blockade therapies unleash breaks in the immune system and induce long-lasting responses. However, a significant number of patients do not respond (innate resistance), and a subset progress after responding (acquired resistance). A better understa...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2017.05.010
更新日期:2017-06-12 00:00:00
abstract::In this issue of Cancer Cell, Nagaraja et al. dissect the molecular mechanisms underlying therapeutic responses to transcriptional disruptors in the fatal pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG). Moreover, they identify super-enhancers mediating these effects, highlighting how normal brain devel...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2017.04.008
更新日期:2017-05-08 00:00:00
abstract::The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene overexpression but is currently considered undruggable. We therefore investigated whether myeloid progenitor cells transformed by Hoxa9 and Meis1 become addicted to targetable signaling pathways. A comprehensive (phospho)proteomic ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2017.03.001
更新日期:2017-04-10 00:00:00
abstract::The dynamic and reversible N6-methyladenosine (m6A) RNA modification installed and erased by N6-methyltransferases and demethylases regulates gene expression and cell fate. We show that the m6A demethylase ALKBH5 is highly expressed in glioblastoma stem-like cells (GSCs). Silencing ALKBH5 suppresses the proliferation ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2017.02.013
更新日期:2017-04-10 00:00:00
abstract::In this issue of Cancer Cell, Wieland et al. uncover a feedback loop in which tumor cells, by augmenting Notch signaling, provoke a senescent and pro-inflammatory state in endothelial cells, promoting neutrophil infiltration, tumor cell adhesion, and metastasis. Interfering with this Notch-dependent crosstalk may be a...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2017.02.016
更新日期:2017-03-13 00:00:00
abstract::Although signaling from phosphatidylinositol 3-kinase (PI3K) and AKT to mechanistic target of rapamycin (mTOR) is prominently dysregulated in high-grade glial brain tumors, blockade of PI3K or AKT minimally affects downstream mTOR activity in glioma. Allosteric mTOR inhibitors, such as rapamycin, incompletely block mT...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2017.01.014
更新日期:2017-03-13 00:00:00
abstract::Aneuploidy is a hallmark of cancer, although its effects on tumorigenesis are unclear. Here, we investigated the relationship between aneuploidy and cancer development using cells engineered to harbor single extra chromosomes. We found that nearly all trisomic cell lines grew poorly in vitro and as xenografts, relativ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2016.12.004
更新日期:2017-02-13 00:00:00
abstract::In this issue of Cancer Cell, Sheltzer et al. shed new light on Theodor Boveri's century-old hypothesis by demonstrating that aneuploidy characterized by single-chromosome gains acts to suppress tumorigenesis and that aneuploidy itself is a nidus for genomic instability. ...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2017.01.011
更新日期:2017-02-13 00:00:00
abstract::The nervous system is emerging as a regulator of malignancy. In this issue of Cancer Cell, Hayakawa et al. demonstrate a feedforward signaling loop in which tumor-derived nerve growth factor promotes enteric tumor innervation, and recruited nerves drive cancer growth through acetylcholine-regulated Wnt signaling and s...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2016.12.008
更新日期:2017-01-09 00:00:00
abstract::Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of anti-tumor immunity and enhanced tumor cell survival. In the current study, we identified tumor necrosis factor alpha (TNF-α) as a major factor triggering cancer cell immunosuppression against T cell surveillance via stabilization...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2016.10.010
更新日期:2016-12-12 00:00:00
abstract::Immune checkpoint-blockade treatments targeting PD-1/PD-L1 have revolutionized cancer therapy. Hence, understanding the regulation of PD-L1 expression has major clinical relevance. In this issue of Cancer Cell, Lim et al. report that inflammation-induced and NF-κB-driven expression of deubiquitinating enzyme CSN5 lead...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2016.11.013
更新日期:2016-12-12 00:00:00
abstract::MicroRNAs (miRNA) are mostly downregulated in cancer. However, the mechanism underlying this phenomenon and the precise consequence in tumorigenesis remain obscure. Here we show that ERK suppresses pre-miRNA export from the nucleus through phosphorylation of exportin-5 (XPO5) at T345/S416/S497. After phosphorylation b...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2016.10.001
更新日期:2016-11-14 00:00:00
abstract::The role of Lyn, both a positive and a negative regulator of B and myeloid cells, in chronic lymphocytic leukemia (CLL) has not been well characterized. In this issue of Cancer Cell, Nguyen et al. demonstrated that Lyn in macrophages rather than in CLL cells is critical for the malignancy. ...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2016.09.018
更新日期:2016-10-10 00:00:00
abstract::Receptor tyrosine kinase (RTK) recycling is of critical importance for RTK signaling and cancer, yet the process is poorly understood. In this issue, Ye et al. identify GOLM1 as a cargo adaptor that drives hepatocellular carcinoma metastasis by promoting EGFR recycling and provide insights into how this process is reg...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2016.08.014
更新日期:2016-09-12 00:00:00
abstract::The EZH2 histone methyltransferase mediates the humoral immune response and drives lymphomagenesis through formation of bivalent chromatin domains at critical germinal center (GC) B cell promoters. Herein we show that the actions of EZH2 in driving GC formation and lymphoma precursor lesions require site-specific bind...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2016.07.006
更新日期:2016-08-08 00:00:00
abstract::Recent genome sequencing efforts have identified millions of somatic mutations in cancer. However, the functional impact of most variants is poorly understood. Here we characterize 194 somatic mutations identified in primary lung adenocarcinomas. We present an expression-based variant-impact phenotyping (eVIP) method ...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2016.06.022
更新日期:2016-08-08 00:00:00
abstract::E proteins and their functional antagonists, the ID proteins, have significant roles in normal hematopoiesis. In this issue of Cancer Cell, Ghisi et al. show that high ID2 levels antagonize self-renewal and promote differentiation of leukemic stem cells in the MLL-translocated molecular subtype of acute myeloid leukem...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2016.06.006
更新日期:2016-07-11 00:00:00
abstract::Obesity increases hepatocellular carcinoma (HCC) risks via unknown mediators. We report that hepatic unconventional prefoldin RPB5 interactor (URI) couples nutrient surpluses to inflammation and non-alcoholic steatohepatitis (NASH), a common cause of HCC. URI-induced DNA damage in hepatocytes triggers inflammation via...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2016.05.020
更新日期:2016-07-11 00:00:00
abstract::Metastasis and therapy resistance are cardinal features of pancreatic ductal adenocarcinoma, a commonly lethal malignancy. In this issue of Cancer Cell, Steele et al. show that CXCR2 expression and neutrophils are required for metastasis. In mice treated with advanced disease, inhibiting both CXCR2 and PD1 cooperative...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2016.05.013
更新日期:2016-06-13 00:00:00
abstract::p62 is a ubiquitin-binding autophagy receptor and signaling protein that accumulates in premalignant liver diseases and most hepatocellular carcinomas (HCCs). Although p62 was proposed to participate in the formation of benign adenomas in autophagy-deficient livers, its role in HCC initiation was not explored. Here we...
journal_title:Cancer cell
pub_type: 杂志文章
doi:10.1016/j.ccell.2016.04.006
更新日期:2016-06-13 00:00:00
abstract::In a recent study, Leucci et al. report a role for the long non-coding RNA SAMMSON in driving mitochondrial function in melanoma. Targeting SAMMSON, the gene of which is frequently co-amplified with MITF, highlights a new cell-type-specific therapeutic vulnerability in melanoma irrespective of BRAF, NRAS, or p53 statu...
journal_title:Cancer cell
pub_type: 评论,杂志文章
doi:10.1016/j.ccell.2016.04.010
更新日期:2016-05-09 00:00:00
abstract::Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now underst...
journal_title:Cancer cell
pub_type: 杂志文章,评审
doi:10.1016/j.ccell.2016.03.010
更新日期:2016-04-11 00:00:00